Hai Xu（Professor）

Name：

Hai Xu

Academic Title：

Professor

Advisor Type：

Supervisor ofPhDandMScstudents

Department：

BiologicalandEnergyChemicalEngineering

Research Interests：

Biological Engineering, Colloid and Interface Chemistry

E-Mail：

xuh@upc.edu.cn

Group Website

https://www.x-mol.com/groups/jiqian

Telephone：

0532-86981569

◎Educational Background

1989-1993, China University of Petroleum (East China), Applied Chemistry，BSc

1994-1997, China University of Petroleum (East China), Applied Chemistry，MSc

1998-2002, China University of Petroleum (East China), Chemical Engineering and Technology，PhD

◎Work Experience

1993-present, China University of Petroleum (East China),Teaching assistant/ Lecturer/Associate Professor /Professor

2003-2005, University of Manchester, Postdoctoral Fellow

◎Research Direction

[1] PeptideDesign, Self-Assembly andPeptide-Based Biomaterials

[2]Enzymes in Industry and Biomimetic Catalysis

[3] Neutron Reflection and Scattering

◎Research Project

[1] NSFC grant:Rational design of peptide co-assembly for the construction and modulation of sophisticated supramolecular systems

[2] NSFC grant:Study of self-assembled peptide nanostructures and dynamics usingsmallangle neutron scattering

[3] NSFC grant:Design and construction of nanometalloenzymes viapeptideself-assembly andtheirstructures andproperties

[4] NSFC grant:Enzyme-mediated hydrogelation and biofunctionalization of short peptide self-assemblies and their application to cell culture

◎Representative Papers and Patents

1. Paper(correspondingauthor in the past five years)

[1] Enzymatically functionalized RGD-gelatin scaffolds that recruit host mesenchymal stem cells in vivo and promote bone regeneration.J. Colloid. InterfaceSci.2022,612,377~391.

[2] Orderedpacking of β-sheetnanofibrils intonanotubes:multi-hierarchicalassembly ofdesignedshortpeptides.Nano Lett2021,21,10199-10207.

[3] Unexpectedrole of achiral glycine in determining the suprastructural handedness of peptide nanofibrils.ACS Nano2021,15, 10328–10341.

[4]Monolayer wall nanotubes self-assembled from short peptide bolaamphiphiles.J. Colloid. InterfaceSci.2021, 583,553-562.

[5] Orderednanofibersfabricated fromhierarchicalself-assemblingprocesses ofdesigned α-helicalpeptides.Small2020,16,45, 2003945.

[6] Dualmode ofanti-biofilmaction of G3 against Streptococcus mutans.ACS Appl. Mater. Interfaces2020,12, 27866-27875.

[7] Surfactant-like peptides: From molecular design to controllable self-assembly with applications.Coord.Chem.Rev.2020,421, 213418.

[8] Rapidhemostasisresulting from thesynergism ofself-assembling short peptide and O-carboxymethyl chitosan.ACS Appl. Mater. Interfaces,2020,12,50, 55574-55583.

[9]Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy.ACS Appl. Mater. Interfaces2019,11, 16357−16366.

[10]Amino acid conformations control the morphological and chiral featuresof the self-assembled peptide nanostructures: Young investigatorsperspective.J.Colloid Interface Sci.2019,548,244–254

[11] Controlling the diameters of nanotubes self-assembled from designed peptide bolaphiles.Small2018,14, 1703216.

[12] Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets.Nat. Commun.2018,9,1, 1-11.

[13] Left or right: How does amino acid chirality affect the handedness of nanostructures self-assembled from short amphiphilic peptides?J. Am. Chem. Soc.2017,139, 4185–4194.

[14] Peptide Self-Assembled Nanostructures with Distinct Morphologies and Properties Fabricated by Molecular Design.ACS Appl. Mater. Interfaces2017,9, 39174-39184.

[15]Rational Design of Short Peptide-Based Hydrogels with MMP‑2Responsiveness for Controlled Anticancer Peptide Delivery.Biomacromolecules2017,18, 3563-3571.

◎Representative Works

[1] Petroleum Composition andConversionChemistry,China University of Petroleum Press, 2008

◎Awards and Honors

[1]National Science Fund for Outstanding Young Scholars of Shandong Province

[2] Education Ministry's New Century Excellent Talents Supporting Plan

◎Courses Offered

Undergraduate：《Biochemistry》

Postgraduate：《Biochemistry and Engineering》

◎Student Training

1.Supervise Postgraduate Students

I have supervised more than 30 PhD and MSc studentsofchemicalengineeringandbioengineering.Mostofthemarenow employedbypetroleumcompanies, colleges, government agencies and other enterprises.SomeofthemarestudyingabroadforPhDdegreein US, Australia and Europe after graduation.

2.Admissions Instructions：

PhD students in Chemical Engineering and Technology.

MSc students in Chemical Engineering and Technology, Biotechnology and Engineering.

◎Part-time Academic Job

[1]Member of Peptide Branch Expert Committee of China Biochemical Pharmaceutical Industry Association

[2] Editorial Board Member of Colloids and Surfaces A

[3]Memberof Shandong Committee of Biochemistry and Molecular Biology