Li Hui（Lecturer）

Name：

Li Hui

Academic Title：

Lecturer

Advisor Type：

Master's Supervisor

Department：

Department of Biological and Energy Chemical Engineering

Research Interests：

Microbial Metabolic Engineering, Genetic Engineering, Enzyme and Protein Engineering

E-Mail：

lihui@upc.edu.cn

Telephone：

15610458295

◎Educational Background

2004-2008, Department of Biotechnology, School of Life Sciences, Shandong University, Bachelor of Science

2008-2013, State Key Laboratory of Microbial Technology, Shandong University, PhD in Microbiology

◎Work Experience

2013 - School of chemistry and chemical engineering, China University of Petroleum (East China), lecturer

◎Research Direction

[1] Biochemical Engineering

[2] Microbial Metabolic Engineering

◎Research Project

[1]Natural Science Foundation of China(31800075),Directional regulationrole and mechanism of TALE-DNA scaffold-mediated multi-enzyme complexes in welan gum biosynthesis, 2019/01-2021/12

[2] Shandong Provincial Natural Science Foundation (ZR2015CL003), Optimization of the biosyntheis pathway of Welan gum by multi-enzyme complexes，2015/08-2017/08

[3] Chinese Postdoc Fund (2014M551981)，The research on biosynthesis pathway and regulation mechanism of welan gum based on genomic sequencing，2014/01-2015/12

[4] Qingdao Postdoc Fund，Construction of engineering strain with high yield of Welan gum and scaling-up of fermentation process，2014/07-2016/01

[5] Fundamental Research Funds for the Central Universities and the Development Fund of State Key Laboratory of Heavy Oil Processing (20CX02202A)，Modification technology of biopolymer Welan gum and development of its surface active derivatives, 2020/05-2022/04

[6] Fundamental Research Funds for the Central Universities (18CX02124A)，Construction of engineering strain with high yield of Welan gum based on the TALE-DNA scaffold-mediated multi-enzyme complexes, 2018/01-2020/12

[7] Fundamental Research Funds for the Central Universities (14CX02124A)，The research on biosynthesis pathway and regulation mechanism of welan gum，2014/01-2015/12，

[8]863 Program (2015AA020925), The biosynthesis pathway of Welan gum in Sphingomonas sp. WG and construction the engineering strain，2015/01-2017/12

◎Representative Papers and Patents

1. Paper

[1]Hui Li,Mengqi Chen, Zaimei Zhang, Benchao Li, Jianlin Liu, Han Xue, Sixue Ji, Zhongrui Guo, Jiqian Wang* and Hu Zhu*.Hybrid Histidine Kinase WelA ofSphingomonassp. WG Contributes to WL Gum Biosynthesis and Motility, Frontiers in Microbiology,2022, 13:792315.

[2]Hui Li, Kehui Li, Zhongrui Guo, Han Xue, Jing Li, Sixue Ji, Jiqian Wang *, Hu Zhu *. The function of β-1,4-glucuronosyltransferase WelK in the sphingan WL gum biosynthesis process in marineSphingomonassp. WG, Marine Biotechnology, 2021, 23: 39-50

[3] Hui Li,Jing Li, Xue Jiao, Kehui Li, Yajie Sun, Wanlong Zhou, Yaling Shen, Jin Qian, Aiping Chang, Jiqian Wang^*, Hu Zhu^*. Characterization of the biosynthetic pathway of nucleotide sugar precursor UDP-glucose during sphingan WL gum production inSphingomonassp. WG. Journal of Biotechnology, 2019, 302:1-9.

[4]Munzer Ullah^#,Hui Li^#, Shi-Wei Sun, Cai-Hong Weng, Hong Zhang, Hu Zhu^*.Polyvinyl alcohol degradation byBacillus cereusRA23 from oil sludge sample.3 BIOTECH,2019, 9:350.

[5]Hui Li,Jing Li, Wanlong Zhou, Xue Jiao, Yajie Sun, Jiqian Wang^*, Hu Zhu^*. An efficient production of a novel carbohydrate polymer Sphingan WL. Journal of Chemical Technology and Biotechnology, 2018, 93: 3472-3482.

[6]Hui Li, Xue Jiao, Wanlong Zhou, Yajie Sun, Wei Liu, Weiping Lin, Ao Liu, Aihua Song, Hu Zhu^*. Enhanced production of total flavones fromInonotus baumiiby multiple strategies. Preparative Biochemistry and Biotechnology, 2018,48(2): 103-112.

2.Patent

[1]Li Hui; Zhu Hu; Sun Yajie; Jiao Xue; Zhou Wanlong; Li Jing; A series of improved pBBR1MCS plasmids and their application, 2019-06-04,, China, ZL201610867175.1

[2] Zhu Hu; Sun Shiwei; Li Hui; Liu Ao; Zhou Wanlong; Dai Xiaoyun; Bu Xiangguo; Application of fig leaf extract with Bacterial Quorum Sensing Inhibition Activity, 2019-12-17, China, ZL201610001371.0

[3] Zhu Hu; Sun Shiwei; Li Hui; Liu Ao; Dai Xiaoyun; Bu Xiangguo; Weng Caihong; A bacterial quorum sensing inhibitor and its application, 2018-10-23, China, zl201610457296.9

[4] Zhu Hu; Sun Shiwei; Li Hui; Sun Jiao; Zhou Wanlong; Liu Ao; The strainRheinheimera aquimarisisolated from marine sludge and its application, 2018-07-06, China, ZL201510393657.3

[5] Zhu Hu; Li Hui; Feng Zhimei; Zhou Wanlong; Sun Yajie; LV Jianren; A Strain and methods for producing Welan gum, 2018-05-08, China, ZL201410485635.5

[6] Zhu Hu; Sun Shiwei; Li Hui; Sun Jiao; Liu Ao; Zhou Wanlong; Isolation, extraction, structural identification and application of a novel quorum sensing inhibitor, 2017-08-11, China，ZL201510436013.8

[7] Ji Sixue, Wang Jiqian, Li Hui, Zhu Hu, Xu Hai, Lu Teng. Biological oil displacement agent Welan gum and its oil displacement system, 2021-02-05, China, ZL201910359615.6,

◎Representative Works

[1] Hui Li, et al. Biological Production of Welan gum. Chapter 4 in Book: Biomaterials- Biological Production of Fuels and Chemicals. Editor: Rafael Luque, Chunping Xu, Publisher: De Gruyter，2016, pages 73-94.

◎Awards and Honors

[1]The 6th Shandong province “Internet plus” college students' innovation and entrepreneurship competition excellent tutor

◎Courses Offered

Undergraduate：《Molecular Biology》《Microorganisms and Human》

Postgraduate：《Genetic Engineering》《Applied Molecular Biology》

◎Student Training

1. Supervise Postgraduate Students

Currently, there are 6 master students. Among the 8 students who graduated, 3 work in biopharmaceutical companies, 1 work in petroleum and petrochemical companies, 3 are engaged in education and 1 is Ph.D. student.

2.Admissions Instructions：

Students majored in Bioengineering, Food Science and Engineering, Chemical Engineering and Technology, Chemistry

◎Part-time Academic Job

[1] Reviewer of Preparative Biochemistry and Biotechnology.